| http://purl.uniprot.org/citations/17570480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17570480 | http://www.w3.org/2000/01/rdf-schema#comment | "The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.04.034"xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Liu J.Q."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Liu Y.'"xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Yang T."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Zheng P."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Wang C.Y."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Chang X."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Love R."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Huang T.H."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Shen R."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Park B.K."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Morrison C."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Zuo T."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Liu C.G."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Godfrey V."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/author | "Chan M.W."xsd:string |
| http://purl.uniprot.org/citations/17570480 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |