| http://purl.uniprot.org/citations/17570665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17570665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17570665 | http://www.w3.org/2000/01/rdf-schema#comment | "Virtual screening against a pCDK2/cyclin A crystal structure led to the identification of a potent and novel CDK2 inhibitor, which exhibited an unusual mode of interaction with the kinase binding motif. With the aid of X-ray crystallography and modelling, a medicinal chemistry strategy was implemented to probe the interactions seen in the crystal structure and to establish SAR. A fragment-based approach was also considered but a different, more conventional, binding mode was observed. Compound selectivity against GSK-3beta was improved using a rational design strategy, with crystallographic verification of the CDK2 binding mode."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2007.04.110"xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2007.04.110"xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Murray J.B."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Murray J.B."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Moore J.D."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Moore J.D."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Lentzen G."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Lentzen G."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Hubbard R.E."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Hubbard R.E."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Borgognoni J."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Borgognoni J."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Dokurno P."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Dokurno P."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Drysdale M.J."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Drysdale M.J."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Howes R."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Howes R."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Surgenor A.E."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Surgenor A.E."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Williamson D.S."xsd:string |
| http://purl.uniprot.org/citations/17570665 | http://purl.uniprot.org/core/author | "Williamson D.S."xsd:string |