| http://purl.uniprot.org/citations/17572495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17572495 | http://www.w3.org/2000/01/rdf-schema#comment | "Fra-1 is overexpressed in a variety of human tumors. Whether MMP-9 expression is regulated by Fra-1 has been contradictory. To clarify the capability of Fra-1 in activating transcription of MMP-9 gene, we analyzed the transcriptional activity of the MMP-9 promoter through the measure of luciferase activities in the MCF-7 cells transiently transfected with Fra-1. The positive regulation of Fra-1 on MMP-9 promoter was not detectable. By the analysis of MMP-9 promoter, a potential Stat3 binding site, just juxtaposed AP-1 consensus sequence, was noticed. The reporter assay showed that MMP-9 promoter was activated remarkably by cotransfection with Fra-1 and Stat3C. DNA affinity precipitation assay confirmed the binding of Stat3 and Fra-1 to the elements of MMP-9 promoter and also revealed c-Jun recruited to Stat3-Fra-1 complex. By immunoprecipitation assay, the Stat3/Fra-1, Stat3/c-Jun and Fra-1/c-Jun complexes were identified in vivo. Our study demonstrated that the activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3. A juxtaposed Stat3/AP-1 element plays a crucial role in the manner of enhancersome in the activation of MMP-9 gene. The functional cooperation of the Stat3 and AP-1 transcription factors is required for the transcription of MMP-9 gene."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2007.04.031"xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Xia Q."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Guo N."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/author | "Yuan G."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/pages | "137-143"xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/title | "Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene."xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/17572495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17572495 |
| http://purl.uniprot.org/citations/17572495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17572495 |
| http://purl.uniprot.org/uniprot/#_E9PKL5-mappedCitation-17572495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17572495 |
| http://purl.uniprot.org/uniprot/#_E9PPX2-mappedCitation-17572495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17572495 |