| http://purl.uniprot.org/citations/17575078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17575078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17575078 | http://www.w3.org/2000/01/rdf-schema#comment | "Disintegrin and metalloprotease proteins (ADAMs) are membrane-anchored glycoproteins involved in cell adhesion, cell fusion, protein ecto-domain shedding, and intracellular signaling. We examined whether the disintegrin domain of ADAM-15 (named ddADAM-15) containing an Asp-Gly-Asp (RGD) integrin-binding motif could interfere with airway smooth muscle cell (ASMC) adhesion and migration. Recombinant ddADAM-15 adhered to human ASMCs with saturation kinetics, and was beta(1)-integrin dependent. ddADAM-15 inhibited the binding of fibrinogen but not of fibronectin to ASMCs. ddADAM-15 also inhibited platelet-derived growth factor (PDGF)-induced ASMC migration, and this was reversed by an anti-beta(1)-integrin antibody. PDGF induced the activation of phosphoinositol-3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK), and selective inhibitors of these kinases inhibited PDGF-induced ASMC migration. ddADAM-15 did not inhibit PDGF-induced activation of PI3K or p38, thereby excluding these kinase pathways as a mechanism by which ddADAM-15 inhibits ASMC migration. ADAM-15 mRNA and protein were expressed under basal conditions, and both gene and protein expression were inhibited by PDGF. In summary, ddADAM-15 inhibits ASMC adhesion and migration through the beta(1)-integrin, without modulating signaling pathways involved in ASMC migratory responses."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2006-0364oc"xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2006-0364oc"xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Lu D."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Lu D."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Xie S."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Xie S."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Chung K.F."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Chung K.F."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Scully M.F."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Scully M.F."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Sukkar M.B."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/author | "Sukkar M.B."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/name | "Am. J. Respir. Cell Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/name | "Am. J. Respir. Cell Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/pages | "494-500"xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/pages | "494-500"xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/title | "Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15."xsd:string |
| http://purl.uniprot.org/citations/17575078 | http://purl.uniprot.org/core/title | "Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15."xsd:string |