| http://purl.uniprot.org/citations/17581316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17581316 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated the simultaneous induction of urokinase-type plasminogen activator and interleukin-8, a CXC chemokine, in doxorubicin-treated human NCI-H69 small cell lung cancer cells in which extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase might be involved. NCI-H69 cells expressed one of the receptor tyrosine kinases, c-Kit, and STI571 inhibited the cell growth and stem cell factor-induced phosphorylation of c-Kit. We therefore investigated the effects of STI571 on the expression of urokinase-type plasminogen activator and interleukin-8 in NCI-H69 cells. Microarray analysis revealed the gene induction of not only urokinase-type plasminogen activator and interleukin-8, but also early growth response-1 in STI571-treated cells. Treatment with STI571 resulted in the induction of phosphorylation of all three mitogen-activated protein kinases, such as extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and stress-activated protein kinase/c-jun N-terminal protein kinase. U0126, an inhibitor against extracellular signal-regulated kinase 1/2, however, only inhibited the STI571-induced interleukin-8 accumulation. Urokinase-type plasminogen activator and interleukin-8 are important biological factors in tumor cell regulation; STI571 may therefore influence many aspects of tumor cell biology through inducing urokinase-type plasminogen activator and interleukin-8, in which the induction of early growth response-1 expression and extracellular signal-regulated kinase 1/2 phosphorylation might be involved."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.org/dc/terms/identifier | "doi:10.1097/mbc.0b013e32815b6465"xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Niiya K."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Tanimoto M."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Yoshida C."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Niiya M."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Asaumi N."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/author | "Shibakura M."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/name | "Blood Coagul Fibrinolysis"xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/pages | "425-433"xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/title | "Induction of urokinase-type plasminogen activator, interleukin-8 and early growth response-1 by STI571 through activating mitogen activated protein kinase in human small cell lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17581316 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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