| http://purl.uniprot.org/citations/17582006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17582006 | http://www.w3.org/2000/01/rdf-schema#comment | "The human cytidine deaminase APOBEC3G (A3G) and other APOBEC3 proteins exhibit differential inhibitory activities against diverse endogenous retroelements and retroviruses, including Vif-deficient human immunodeficiency virus type 1. The potential inhibitory activity of human APOBEC proteins against long interspersed element 1 (LINE-1) has not been fully evaluated. Here, we demonstrate inhibition of LINE-1 by multiple human APOBEC3 cytidine deaminases, including previously unreported activity for A3DE and A3G. More ancient members of APOBEC, cytidine deaminases AID and APOBEC2, had no detectable activity against LINE-1. A3A, which did not form high-molecular-mass (HMM) complexes and interacted poorly with P bodies, was the most potent inhibitor of LINE-1. A3A specifically recognizes LINE-1 RNA but not the other cellular RNAs tested. However, in the presence of LINE-1, A3A became associated with HMM complexes containing LINE-1 RNA. The ability of A3A to recognize LINE-1 RNA required its catalytic domain and was important for its LINE-1 suppression. Although the mechanism of LINE-1 restriction did not seem to involve DNA editing, A3A inhibited the accumulation of nascent LINE-1 DNA, suggesting interference with LINE-1 reverse transcription and/or integration or intracellular movement of LINE-1 ribonucleoprotein. Thus, association with P bodies or cellular HMM complexes could not predict the potency of APOBEC3 anti-LINE-1 activities. The catalytic domain of APOBEC3 proteins may be important for proper folding and target factors such as RNA or protein interaction in addition to cytidine deamination."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02800-06"xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Tan L."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Sarkis P.T."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Yu X.F."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/author | "Niewiadomska A.M."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/pages | "9577-9583"xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/title | "Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association."xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17582006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17582006 |
| http://purl.uniprot.org/citations/17582006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17582006 |
| http://purl.uniprot.org/uniprot/#_M4VP52-mappedCitation-17582006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17582006 |
| http://purl.uniprot.org/uniprot/#_Q59GY0-mappedCitation-17582006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17582006 |
| http://purl.uniprot.org/uniprot/#_Q9NRW3-mappedCitation-17582006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17582006 |
| http://purl.uniprot.org/uniprot/Q59GY0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17582006 |
| http://purl.uniprot.org/uniprot/Q9NRW3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17582006 |
| http://purl.uniprot.org/uniprot/M4VP52 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17582006 |