| http://purl.uniprot.org/citations/17582772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17582772 | http://www.w3.org/2000/01/rdf-schema#comment | "Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p<0.0001), indicating a small fibre neuropathy. TRPV1-positive fibres were overall significantly increased in BMS (p=0.0011), as were NGF fibres (p<0.0001) and basal epithelial cell NGF staining (p<0.0147). There was a significant correlation between the baseline pain score and TRPV1 (p=0.0143) and NGF fibres (p=0.0252). A significant correlation was observed between baseline and post-capsaicin pain (p=0.0006). Selective TRPV1 and NGF blockers may provide a new therapy for BMS."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jocn.2006.09.002"xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Bountra C."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Anand P."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Yiangou Y."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Chessell I.P."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Renton T."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Yilmaz Z."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/author | "Zakrzewska J."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/name | "J Clin Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/pages | "864-871"xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/title | "Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score."xsd:string |
| http://purl.uniprot.org/citations/17582772 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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