| http://purl.uniprot.org/citations/17586086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17586086 | http://www.w3.org/2000/01/rdf-schema#comment | "It is becoming increasingly evident that the urocortins (Ucns) and their receptors are involved in the initiation and development of inflammation in the gastrointestinal (GI) tract. There has not been a systematic study of the basal expression of Ucns or their receptors in the GI tract. Here, we examined basal expression of Ucn 2 and its high-affinity receptor, CRF-R2 in the rat GI tract. Ucn 2 mRNA was expressed throughout the small and large intestine. Surprisingly, CRF-R2 mRNA expression was detected in only a subset of GI regions that expressed Ucn 2. Immunohistochemical study showed that both Ucn 2 immuno-reactivity (Ucn 2-IR) and CRF-R2-IR were consistently seen in the neurons of the myenteric plexus and the nerve fibers innervating the circular muscle. By and large, Ucn 2-IR was detected in all layers, including the mucosal and the submucosal layers throughout the GI regions. In contrast, CRF-R2-IR was very low or undetectable in the mucosal layers of all regions examined. The role of Ucn 2 and CRF-R2 was then examined in a rat model of chemically-induced colitis. In the early phase of colitis, Ucn 2 mRNA levels peaked, whereas, in striking contrast, CRF-R2 mRNA expression decreased approximately 2.5-fold below control levels. At the peptide level, Ucn 2-IR was specifically induced in a large population of immune cells that infiltrated the lamina propria and submucosa of the distal colon, whereas CRFR2-IR was detected in only a small fraction of infiltrated immune cells. CRF-R2-IR was dramatically reduced in the neurons of the myenteric plexus. Thus, we show, for the first time, that in the acute phase of inflammation, Ucn 2 levels are increased whereas expression levels of its only identified receptor, CRF-R2, are decreased. This suggests that Ucn 2 exerts its effects only in part via CRF-R2."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2007.05.008"xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Chang J."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Bhargava A."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Idumalla P.S."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Clifton M.S."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Hoy J.J."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/author | "Pecoraro N.C."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/pages | "1453-1460"xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/title | "Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis."xsd:string |
| http://purl.uniprot.org/citations/17586086 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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