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http://purl.uniprot.org/citations/17588138http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17588138http://www.w3.org/2000/01/rdf-schema#comment"

Objective and design

Recent data suggest that extracellular Hsp60 modulates the host innate immune response. We analyzed plasma Hsp60 levels in children admitted to a level III tertiary care PICU with septic shock.

Materials and subjects

Blood samples were obtained from children meeting criteria for septic shock (n = 63), critically ill children without septic shock (n = 10), and healthy controls (n = 24).

Treatment

Not applicable.

Methods

Hsp60 levels were measured in the plasma using a commercially available ELISA. Differences between groups were analyzed with a Kruskal-Wallis one way ANOVA due to the non-parametric nature of the data. A p value < or = 0.05 was considered significant.

Results

Extracellular Hsp60 levels were significantly higher in children with septic shock (median, 16.7 ng/mL) compared to both critically ill children without septic shock (median, 0 ng/mL) and healthy controls (median, 0 ng/mL, p <0.001).

Conclusions

Extracellular Hsp60 levels are significantly elevated in children with septic shock compared with both healthy controls and critically ill children without sepsis. Extracellular Hsp60 may play a role in the pathogenesis of sepsis in children."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.org/dc/terms/identifier"doi:10.1007/s00011-007-6108-4"xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Wheeler D.S."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Carcillo J.A."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Wong H.R."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Odoms K."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Doughty L.A."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Jacobs B.R."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/author"Lahni P."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/pages"216-219"xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/title"Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock."xsd:string
http://purl.uniprot.org/citations/17588138http://purl.uniprot.org/core/volume"56"xsd:string
http://purl.uniprot.org/citations/17588138http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17588138
http://purl.uniprot.org/citations/17588138http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17588138
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http://purl.uniprot.org/uniprot/#_B7Z4F6-mappedCitation-17588138http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17588138
http://purl.uniprot.org/uniprot/#_B7Z532-mappedCitation-17588138http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17588138
http://purl.uniprot.org/uniprot/#_B3GQS7-mappedCitation-17588138http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17588138
http://purl.uniprot.org/uniprot/#_B7Z597-mappedCitation-17588138http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17588138
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