| http://purl.uniprot.org/citations/17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17588539 | http://www.w3.org/2000/01/rdf-schema#comment | "Diacylglycerol kinase (DGK) is one of lipid-regulating enzymes, catalyzes phosphorylation of diacylglycerol to phosphatidic acid. Because skeletal muscle, a major insulin-target organ for glucose disposal, expresses DGK, we investigated in the present study a role of DGK on glucose transport in skeletal muscle cells. PCR study showed that C2C12 myotubes expressed DGKalpha, delta, epsilon, zeta, or theta isoform mRNA. R59022, a specific inhibitor of DGK, significantly increased glucose transport, p38 and MKK3/6 activation in C2C12 myotubes. The R59022-induced glucose transport was blocked by SB203580, a specific p38 inhibitor. In contrast, R59022 failed to stimulate both possible known mechanisms to enhance glucose transport, an IRS1-PI3K-Akt pathway, muscle contraction signaling or GLUT1 and 4 expression. All these results suggest that DGK may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3/6-p38 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.06.040"xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Nagamine M."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Okumura T."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Motomura W."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Kohgo Y."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/author | "Tanno S."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/pages | "244-250"xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/title | "A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells."xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/17588539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17588539 |
| http://purl.uniprot.org/citations/17588539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17588539 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Q6-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_O09110-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_Q60521-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_Q3TX82-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_Q8BP44-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_Q3UDI2-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_Q5SWN9-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_P47811-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |
| http://purl.uniprot.org/uniprot/#_P70236-mappedCitation-17588539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17588539 |