| http://purl.uniprot.org/citations/17588931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17588931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17588931 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin, which is best known as a cytoskeletal component, also participates in the control of gene expression. We report a function of nuclear actin in the regulation of MAL, a coactivator of the transcription factor serum response factor (SRF). MAL, which binds monomeric actin, is cytoplasmic in many cells but accumulates in the nucleus upon serum-induced actin polymerization. MAL rapidly shuttles between cytoplasm and nucleus in unstimulated cells. Serum stimulation effectively blocks MAL nuclear export, which requires MAL-actin interaction. Nuclear MAL binds SRF target genes but remains inactive unless actin binding is disrupted. Fluorescence resonance energy transfer analysis demonstrates that the MAL-actin interaction responds to extracellular signals. Serum-induced signaling is thus communicated to nuclear actin to control a transcriptional regulator."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1141084"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1141084"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Treisman R."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Treisman R."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Guettler S."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Guettler S."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Larijani B."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/author | "Larijani B."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/pages | "1749-1752"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/pages | "1749-1752"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/title | "Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/title | "Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL."xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/17588931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17588931 |
| http://purl.uniprot.org/citations/17588931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17588931 |