| http://purl.uniprot.org/citations/17591955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17591955 | http://www.w3.org/2000/01/rdf-schema#comment | "Fas/Fas ligand (Fas-L) engagement, a potent inducer of apoptosis, is also important for cellular activation, regulation of effector and chemotactic activity, and secretion of chemokines and cytokines. We evaluated the relevance of Fas/Fas-L in the regulation of myocarditis induced by Trypanosoma cruzi infection and observed that in Fas-L(-/-) mice (gld/gld), cardiac infiltration was significantly reduced, accordingly showing less cardiomyocyte destruction. Fluorescence-activated cell sorting analysis of cardiac inflammatory cells showed higher numbers of CD8(+) T cells in BALB/c compared with gld/gld mice but similar levels of lymphocyte function-associated antigen-1, intercellular adhesion molecule, CD2, and CD69 expression; MAC-1(+) myeloid cells and mast cells were increased in BALB/c mice, whereas gld/gld mice exhibited an enrichment of CD4(+/low) T cells. Intracellular labeling of cytokines revealed no clear cardiac skewing of Th1 or Th2 responses, but we found a higher number of interleukin-10(+) cells in gld/gld mice and a deficient expression of vascular cell adhesion molecule-1 on cardiac endothelial cells in gld/gld mice. Finally, we found a population of CD3(+) but CD4/CD8 double negative cardiac T cells in both groups of infected mice, but down-regulation of some adhesion molecules and surface receptors was only observed in gld/gld mice, indicating a targeted T-cell population mostly affected by the lack of Fas-L engagement. These results point to a role for myocarditis regulation by Fas/Fas-L beyond its possible direct relevance in cellular death."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2007.060643"xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "Batista M.M."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "de Oliveira G.M."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "Batista W."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "Henriques-Pons A."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "Bani Correa C."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "Diniz R.L."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/author | "de Araujo-Jorge T.C."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/pages | "79-86"xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/title | "Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection."xsd:string |
| http://purl.uniprot.org/citations/17591955 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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