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http://purl.uniprot.org/citations/17593080http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17593080http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Tyrosine kinase receptors Her2/neu and c-Met play an important role in breast cancer development and progression. Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by two different immunocytochemical techniques, classical immunohistochemistry and immunofluorescence, and to correlate their expression levels with histopathological and clinical characteristics.

Methods and results

Both methods revealed similar c-Met staining patterns in both the in situ component and the adjacent normal tissue (P < 0.001). However, an imbalance in c-Met expression between tumour and surrounding normal tissue was correlated with high-grade DCIS (Van Nuys Grade 3). No correlation existed between Her2/neu and c-Met expression. High HGF/SF immunoreactivity was observed in 43.6% of the cases, yet the adjacent cellular stroma revealed only low levels of HGF/SF. No correlation existed between c-Met, Her2/neu or HGF/SF expression and clinicopathological factors.

Conclusion

An imbalance in c-Met expression between tumour and surrounding normal tissue is associated with an aggressive DCIS phenotype. Moreover, c-Met and HGF/SF may contribute to tumour development by different means than those controlled by Her2/neu."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2559.2007.02732.x"xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Schafer J."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Vande Woude G.F."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Resau J."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Lengyel E."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Harbeck N."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Welk A."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Nahrig J."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Annecke K."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Kort E."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Leeser B."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/author"Lindemann K."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/name"Histopathology"xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/pages"54-62"xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/title"Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue."xsd:string
http://purl.uniprot.org/citations/17593080http://purl.uniprot.org/core/volume"51"xsd:string
http://purl.uniprot.org/citations/17593080http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17593080
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