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http://purl.uniprot.org/citations/17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17595763http://www.w3.org/2000/01/rdf-schema#comment"

Background

The expression of tumour suppressor p53 and oncogene c-myc was investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats.

Materials and methods

Tissue sections ranging from normal mucosa to moderately differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against mutant p53 and c-myc proteins.

Results

From hyperplasia to later stages of oral oncogenesis, mutant p53 expression was at higher levels in diabetic rats in comparison to normal animals, although the pattern of expression was similar. In contrast, c-myc expression was significantly higher in diabetic than in normal rats only in normal mucosa and hyperplasia.

Conclusion

It seems that diabetes contributed to increased accumulation of mutations in the p53 gene, contributing to increased proliferation of tumour cells during oral oncogenesis. Additionally, diabetes appeared to enhance c-myc expression only in the initial stages of oral oncogenesis."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Vassiliou S."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Patsouris E."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Lazaris A."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Yapijakis C."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Derka S."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Vairaktaris E."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Vylliotis A."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Nkenke E."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Spyridonidou S."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Goutzanis L."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/author"Kalokerinos G."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/pages"1465-1473"xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/title"Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis."xsd:string
http://purl.uniprot.org/citations/17595763http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/17595763http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17595763
http://purl.uniprot.org/citations/17595763http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17595763
http://purl.uniprot.org/uniprot/#_A0A0G2KB75-mappedCitation-17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17595763
http://purl.uniprot.org/uniprot/#_A0A0G2KBB2-mappedCitation-17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17595763
http://purl.uniprot.org/uniprot/#_P10361-mappedCitation-17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17595763
http://purl.uniprot.org/uniprot/#_A0A8I5ZQW3-mappedCitation-17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17595763
http://purl.uniprot.org/uniprot/#_A0A0G2JTP9-mappedCitation-17595763http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17595763
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