| http://purl.uniprot.org/citations/17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17596205 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently reported that keratin 14-promoter-driven vascular endothelial growth factor (VEGF)-E(NZ-7) transgenic mice have a significant number of capillary vessels in subcutaneous tissue. However, these vessels are generated in a layer some distance from the epithelial basal cells that express VEGF-E(NZ-7), suggesting that one or more antiangiogenenic molecules may exist very near the basal cell layer. By screening keratinocyte-conditioned medium, we found that thrombospondin-1 (TSP-1) is produced from keratinocytes and suppresses human umbilical vein endothelial cells (HUVEC) growth as well as tubular formation in a HUVEC-fibroblast coculture system. Different to the known mechanism of CD36-dependent endothelial cell apoptosis, the HUVEC we used did not express CD36 at detectable levels, indicating a new mechanism for TSP-1-induced antiangiogenesis. We found that TSP-1 induces little apoptosis of endothelial cells but causes cell-cycle arrest, increasing the amounts of p21(CIP/WAF-1) and unphosphorylated retinoblastoma (Rb) in HUVEC. CD36-binding peptide in TSP-1 and CD36-neutralizing antibody did not block the TSP-1-induced cell-cycle arrest. Our results strongly suggest that TSP-1 utilizes a novel pathway for its antiangiogenic effect independent of CD36, and suppresses the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2007.00534.x"xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/author | "Shibuya M."xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/author | "Imajoh-Ohmi S."xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/author | "Yamauchi M."xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/pages | "1491-1497"xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/title | "Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/17596205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17596205 |
| http://purl.uniprot.org/citations/17596205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17596205 |
| http://purl.uniprot.org/uniprot/P07996#attribution-1606D2DDCE117193E2FF81D8B4EA0A6C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK25-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_A0PJG0-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_B4DDK8-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_Q12928-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_P07996-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/#_Q7KYY3-mappedCitation-17596205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/P07996 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/Q7KYY3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/A0A0B6XK25 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/A0PJG0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17596205 |
| http://purl.uniprot.org/uniprot/B4DDK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17596205 |