| http://purl.uniprot.org/citations/17596444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17596444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17596444 | http://www.w3.org/2000/01/rdf-schema#comment | "The dynamic interplay between serotonin [5-hydroxytryptamine (5-HT)] neurotransmission and the hypothalamic-pituitary-adrenal (HPA) axis has been extensively studied over the past 30 years, but the underlying mechanism of this interaction has not been defined. A possibility receiving little attention is that 5-HT regulates upstream corticotropin-releasing hormone (CRH) signaling systems via activation of serotonin 2C receptors (5-HT(2C)Rs) in the paraventricular nucleus of the hypothalamus (PVH). Through complementary approaches in wild-type rodents and 5-HT(2C)R-deficient mice, we determined that 5-HT(2C)Rs are necessary for 5-HT-induced HPA axis activation. We used laser-capture PVH microdissection followed by microarray analysis to compare the expression of 13 5-HTRs. Only 5-HT(2C)R and 5-HT(1D)R transcripts were consistently identified as present in the PVH, and of these, the 5-HT(2C)R was expressed at a substantially higher level. The abundant expression of 5-HT(2C)Rs in the PVH was confirmed with in situ hybridization histochemistry. Dual-neurohistochemical labeling revealed that approximately one-half of PVH CRH-containing neurons coexpressed 5-HT(2C)R mRNA. We observed that PVH CRH neurons consistently depolarized in the presence of a high-affinity 5-HT(2C)R agonist, an effect blocked by a 5-HT(2C)R antagonist. Supporting the importance of 5-HT(2C)Rs in CRH neuronal activity, genetic inactivation of 5-HT(2C)Rs produced a downregulation of CRH mRNA and blunted CRH and corticosterone release after 5-HT compound administration. These findings thus provide a mechanistic explanation for the longstanding observation of HPA axis stimulation in response to 5-HT and thereby give insight into the neural circuitry mediating the complex neuroendocrine responses to stress."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2584-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2584-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Colmers W.F."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Colmers W.F."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Elmquist J.K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Elmquist J.K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Heisler L.K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Heisler L.K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Nonogaki K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Nonogaki K."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "O'Rahilly S."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "O'Rahilly S."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Pronchuk N."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Pronchuk N."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Raber J."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Raber J."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Tecott L.H."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Tecott L.H."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Tung L."xsd:string |
| http://purl.uniprot.org/citations/17596444 | http://purl.uniprot.org/core/author | "Tung L."xsd:string |