| http://purl.uniprot.org/citations/17599067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17599067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17599067 | http://www.w3.org/2000/01/rdf-schema#comment | "TANK-binding kinase 1 (TBK1/NAK/T2K) and I-kappaB Kinase (IKK-i/IKK-epsilon) play important roles in the regulation of interferon (IFN)-inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram-negative bacteria leads to activation of TBK1 or IKK-i, which in turn phosphorylates the transcription factors, IFN-regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK-i and identified a ubiquitin-like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK-i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN-beta or RANTES promoters. The importance of the ULD of TBK1 in LPS- or poly(I:C)-stimulated IFN-beta production was demonstrated by reconstitution experiments in TBK1-IKK-i-deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK-i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601773"xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601773"xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Dikic I."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Dikic I."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Ikeda F."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Ikeda F."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Dotsch V."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Dotsch V."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Rogov V."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Rogov V."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Rozenknop A."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Rozenknop A."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Hecker C.M."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Hecker C.M."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Nordmeier R.D."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/author | "Nordmeier R.D."xsd:string |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17599067 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |