| http://purl.uniprot.org/citations/17599806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17599806 | http://www.w3.org/2000/01/rdf-schema#comment | "High-mobility group box 1 (HMGB1) is a nuclear factor released extracellularly as a proinflammatory cytokine. We measured the HMGB1 concentration in the sera of mice with chemically induced colitis (DSS; dextran sulfate sodium salt) and found a marked increase. Inhibition of HMGB1 by neutralizing anti-HMGB1 antibody resulted in reduced inflammation in DSS-treated colons. In macrophages, HMGB1 induces several proinflammatory cytokines, such as IL-6, which are regulated by NF-kappaB activation. Two putative sources of HMGB1 were explored: in one, bacterial factors induce HMGB1 secretion from macrophages and in the other, necrotic epithelial cells directly release HMGB1. LPS induced a small amount of HMGB1 in macrophages, but macrophages incubated with supernatant prepared from necrotic cells and containing large amounts of HMGB1 activated NF-kappaB and induced IL-6. Using the colitis-associated cancer model, we demonstrated that neutralizing anti-HMGB1 antibody decreases tumor incidence and size. These observations suggest that HMGB1 is a potentially useful target for IBD treatment and the prevention of colitis-associated cancer."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.06.065"xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Maeda S."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Yanai A."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Omata M."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Shibata W."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Hikiba Y."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/author | "Ohmae T."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/pages | "394-400"xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/title | "Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer."xsd:string |
| http://purl.uniprot.org/citations/17599806 | http://purl.uniprot.org/core/volume | "360"xsd:string |
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