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| http://purl.uniprot.org/citations/17600711 | http://www.w3.org/2000/01/rdf-schema#comment | "EB1 is a small microtubule (MT)-binding protein that associates preferentially with MT plus ends and plays a role in regulating MT dynamics. EB1 also targets other MT-associated proteins to the plus end and thereby regulates interactions of MTs with the cell cortex, mitotic kinetochores, and different cellular organelles [1, 2]. EB1 also localizes to centrosomes and is required for centrosomal MT anchoring and organization of the MT network [3, 4]. We previously showed that EB1 localizes to the flagellar tip and proximal region of the basal body in Chlamydomonas[5], but the function of EB1 in the cilium/flagellum is unknown. We depleted EB1 from NIH3T3 fibroblasts by using siRNA and found that EB1 depletion causes a approximately 50% reduction in the efficiency of primary cilia assembly in serum-starved cells. Expression of dominant-negative EB1 also inhibited cilia formation, and expression of mutant dominant-negative EB1 constructs suggested that binding of EB1 to p150(Glued) is important for cilia assembly. Finally, expression of a C-terminal fragment of the centrosomal protein CAP350, which removes EB1 from the centrosome but not MT plus ends [6], also inhibited ciliogenesis. We conclude that localization of EB1 at the centriole/basal body is required for primary cilia assembly in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2007.05.055"xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/author | "Schneider L."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/author | "Pedersen L.B."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/author | "Christensen S.T."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/author | "Schroder J.M."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/pages | "1134-1139"xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/title | "EB1 is required for primary cilia assembly in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/17600711 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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