| http://purl.uniprot.org/citations/17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17607320 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA) is an important negative regulator of T-cell activation. T-cell activation involves partitioning of receptors into discrete membrane compartments known as lipid rafts and the formation of an immunological synapse (IS) between the T cell and antigen-presenting cell (APC). Here we show that after T-cell stimulation, BTLA co-clusters with the CD3zeta and is then involved in IS, as determined by a two-photon microscope. BTLA can interact with the phosphorylated form of T-cell receptor (TCR) within the lipid raft, which is associated with the T-cell signaling complex. Coligation of BTLA with the TCR significantly decreased the amount of phosphorylated TCR-related signal accumulation in the lipid raft during T-cell activation. These results suggest that BTLA functions to regulate T-cell signaling by controlling the phosphorylated form of TCRzeta accumulation in the lipid raft."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.icb.7100087"xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/author | "Zhen Y."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/author | "Zeng C."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/author | "Yi H.F."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/author | "Wu T.H."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/name | "Immunol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/pages | "590-595"xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/title | "B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/17607320 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17607320 |
| http://purl.uniprot.org/citations/17607320 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17607320 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A0-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_A2MZG6-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_E9QNY6-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_Q32MV8-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_P24161-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_Q32MV9-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_Q3UU54-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
| http://purl.uniprot.org/uniprot/#_Q7TSA3-mappedCitation-17607320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607320 |
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| http://purl.uniprot.org/uniprot/E9QNY6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17607320 |