| http://purl.uniprot.org/citations/17607499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17607499 | http://www.w3.org/2000/01/rdf-schema#comment | "To evaluate the relationship between plasma concentration of amino-terminal fragment of pro-brain natriuretic peptide (NT-proBNP), functional capacity, and right ventricular overload in survivors of tetralogy of Fallot (TOF) repair, we prospectively studied 70 operated TOF patients (44 males, 21 +/-1 years old; mean +/-SEM) who underwent, during the same day, echocardiography, cardiac magnetic resonance imaging, neurohormonal characterization (plasma NT-proBNP, catecholamines, plasma renin activity, and aldosterone assay), and cardiopulmonary exercise testing. Forty-eight age- and sex-matched healthy volunteers served as the control group. Compared to controls, maximal workload and peak oxygen consumption (VO2/kg) were lower in operated TOF patients (p < 0.001), whereas NT-proBNP concentration was elevated (p < 0.001). No difference was found among the other neurohormones. In operated TOF patients, NT-proBNP showed a significant positive correlation with right ventricular (RV) end systolic and end diastolic volumes and RV systolic pressure, and it showed a negative correlation with peak VO2/kg and RV ejection fraction. From multivariable analysis, NT-proBNP concentration was found to be an independent predictor of peak VO2/kg, RV end systolic volume, and RV systolic pressure. These results show an association among RV overload, decrease in functional capacity, and cardiac natriuretic peptide expression in operated TOF patients. NT-proBNP plasma assay may be a useful tool for diagnostic purposes and for decision making in this setting."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00246-007-0009-8"xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Emdin M."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Fontana M."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Ait-Ali L."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "De Marchi D."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Festa P."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Passino C."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/author | "Prontera C."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/name | "Pediatr Cardiol"xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/pages | "339-345"xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/title | "Amino-terminal fragment of pro-brain natriuretic hormone identifies functional impairment and right ventricular overload in operated tetralogy of Fallot patients."xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/17607499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17607499 |
| http://purl.uniprot.org/citations/17607499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17607499 |
| http://purl.uniprot.org/uniprot/#_P16860-mappedCitation-17607499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607499 |
| http://purl.uniprot.org/uniprot/P16860 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17607499 |