| http://purl.uniprot.org/citations/17607765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17607765 | http://www.w3.org/2000/01/rdf-schema#comment | "The anatomical distribution of sensory-evoked activity recorded from the hippocampal long-axis can shift depending on prior experience. In accordance with Marr's computational model of hippocampal function, CA3 NMDA receptors have been hypothesized to mediate this experience-dependent shift in hippocampal activity. Here we tested this hypothesis by investigating genetically-modified mice in which CA3 NMDA receptors are selectively knocked-out (CA3-NR1 KO). First, we were required to develop an fMRI protocol that can record sensory-evoked activity from the mouse hippocampal long-axis. This goal was achieved in part by using a dedicated mouse scanner to image odor-evoked activity, and by using non-EPI (echo planer imaging) pulse sequences. As in humans, odors were found to evoke a ventral-predominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner. Finally, we found that the experience-dependent shift in hippocampal long-axis activity is blocked in CA3-NR1 knock-out mice. These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.org/dc/terms/identifier | "doi:10.1002/hipo.20332"xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/author | "Tonegawa S."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/author | "Small S.A."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/author | "Kent K."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/author | "Hess K."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/name | "Hippocampus"xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/pages | "1003-1011"xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/title | "CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity."xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/17607765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17607765 |
| http://purl.uniprot.org/citations/17607765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17607765 |
| http://purl.uniprot.org/uniprot/#_A2AI16-mappedCitation-17607765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607765 |
| http://purl.uniprot.org/uniprot/#_P35438-mappedCitation-17607765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607765 |
| http://purl.uniprot.org/uniprot/#_Q3TZ31-mappedCitation-17607765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17607765 |
| http://purl.uniprot.org/uniprot/Q3TZ31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17607765 |
| http://purl.uniprot.org/uniprot/P35438 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17607765 |
| http://purl.uniprot.org/uniprot/A2AI16 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17607765 |