| http://purl.uniprot.org/citations/17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609108 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinase 1 (Cdk1) initiates mitosis and later activates the anaphase-promoting complex/cyclosome (APC/C) to destroy cyclins. Kinetochore-derived checkpoint signaling delays APC/C-dependent cyclin B destruction, and checkpoint-independent mechanisms cooperate to limit APC/C activity when kinetochores lack checkpoint components in early mitosis. The APC/C and cyclin B localize to the spindle and poles, but the significance and regulation of these populations remain unclear. Here we describe a critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, that spatially restricts APC/C activity in early mitosis. The APC/C inhibitor Emi1 binds the spindle-organizing NuMA/dynein-dynactin complex to anchor and inhibit the APC/C at spindle poles, and thereby limits destruction of spindle-associated cyclin B. Cyclin B/Cdk1 activity recruits the END network and establishes a positive feedback loop to stabilize spindle-associated cyclin B critical for spindle assembly. The organization of the APC/C on the spindle also provides a framework for understanding microtubule-dependent organization of protein destruction."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.04.017"xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Mikhailov A."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Jackson P.K."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Miller J.J."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Nachury M.V."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Tung J.J."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Rieder C.L."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Torres J.Z."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/author | "Ban K.H."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/pages | "29-42"xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/title | "The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis."xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17609108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17609108 |
| http://purl.uniprot.org/citations/17609108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17609108 |
| http://purl.uniprot.org/uniprot/#_A8K394-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_B2RB17-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_G1UI36-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_Q14980-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_Q7Z757-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_Q4LE64-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |
| http://purl.uniprot.org/uniprot/#_Q59HB8-mappedCitation-17609108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609108 |