| http://purl.uniprot.org/citations/17609109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609109 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple modes of endocytosis require actin-dependent remodeling of the plasma membrane; however, neither the factors linking these processes nor their mechanisms of action are understood. The sorting nexin, SNX9, localizes to clathrin-coated pits where it interacts with dynamin and functions in clathrin-mediated endocytosis. Here, we demonstrate that SNX9 also localizes to actin-rich structures implicated in fluid-phase uptake, including tubular membranes containing GPI-anchored proteins and dorsal membrane ruffles. Moreover, we show that SNX9 is critical for dorsal ruffle formation and for clathrin-independent, actin-dependent fluid-phase endocytosis. In vitro, SNX9 directly associates with N-WASP, an Arp2/3 complex activator, and stimulates N-WASP/Arp2/3-mediated actin assembly. SNX9-stimulated actin polymerization is greatly enhanced by PI(4,5)P(2)-containing liposomes, due in part to PI(4,5)P(2)-induced SNX9 oligomerization. These results suggest a mechanism for the spatial and temporal regulation of N-WASP-dependent actin assembly and implicate SNX9 in directly coupling actin dynamics to membrane remodeling during multiple modes of endocytosis."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.04.014"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.04.014"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Schmid S.L."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Schmid S.L."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Waterman-Storer C.M."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Waterman-Storer C.M."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Yarar D."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/author | "Yarar D."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/pages | "43-56"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/pages | "43-56"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/title | "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/title | "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis."xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17609109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17609109 |
| http://purl.uniprot.org/citations/17609109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17609109 |
| http://purl.uniprot.org/citations/17609109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17609109 |
| http://purl.uniprot.org/citations/17609109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17609109 |