| http://purl.uniprot.org/citations/17609115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609115 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, the Gli-family transcription factor TRA-1 is the terminal effector of the sex-determination pathway. TRA-1 activity inhibits male development and allows female fates. Genetic studies have indicated that TRA-1 is negatively regulated by the fem-1, fem-2, and fem-3 genes. However, the mechanism of this regulation has not been understood. Here, we present data that TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex that contains FEM-1 as the substrate-recognition subunit, and FEM-2 and FEM-3 as cofactors. CUL-2 physically associates with both FEM-1 and TRA-1 in vivo, and cul-2 mutant males share feminization phenotypes with fem mutants. CUL-2 and the FEM proteins negatively regulate TRA-1 protein levels in C. elegans. When expressed in human cells, the FEM proteins interact with human CUL2 and induce the proteasome-dependent degradation of TRA-1. This work demonstrates that the terminal step in C. elegans sex determination is controlled by ubiquitin-mediated proteolysis."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.05.008"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.05.008"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Kipreos E.T."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Kipreos E.T."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Starostina N.G."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Starostina N.G."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Wells L."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Wells L."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Lim J.M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Lim J.M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Schvarzstein M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Schvarzstein M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Spence A.M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/author | "Spence A.M."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/pages | "127-139"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/pages | "127-139"xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/title | "A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination."xsd:string |
| http://purl.uniprot.org/citations/17609115 | http://purl.uniprot.org/core/title | "A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination."xsd:string |