| http://purl.uniprot.org/citations/17609428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17609428 | http://www.w3.org/2000/01/rdf-schema#comment | "In CD34(+) acute myeloid leukemia (AML), the malignant stem cells reside in the CD38(-) compartment. We have shown before that the frequency of such CD34(+)CD38(-) cells at diagnosis correlates with minimal residual disease (MRD) frequency after chemotherapy and with survival. Specific targeting of CD34(+)CD38(-) cells might thus offer therapeutic options. Previously, we found that C-type lectin-like molecule-1 (CLL-1) has high expression on the whole blast compartment in the majority of AML cases. We now show that CLL-1 expression is also present on the CD34(+)CD38(-) stem-cell compartment in AML (77/89 patients). The CD34(+)CLL-1(+) population, containing the CD34(+)CD38(-)CLL-1(+) cells, does engraft in nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice with outgrowth to CLL-1(+) blasts. CLL-1 expression was not different between diagnosis and relapse (n = 9). In remission, both CLL-1(-) normal and CLL-1(+) malignant CD34(+)CD38(-) cells were present. A high CLL-1(+) fraction was associated with quick relapse. CLL-1 expression is completely absent both on CD34(+)CD38(-) cells in normal (n = 11) and in regenerating bone marrow controls (n = 6). This AML stem-cell specificity of the anti-CLL-1 antibody under all conditions of disease and the leukemia-initiating properties of CD34(+)CLL-1(+) cells indicate that anti-CLL-1 antibody enables both AML-specific stem-cell detection and possibly antigen-targeting in future."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-03-083048"xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Stigter-van Walsum M."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Feller N."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Ossenkoppele G.J."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "van Dongen G.A."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Zweegman S."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Rombouts E.J."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Jan Schuurhuis G."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Kelder A."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "Moshaver B."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/author | "van Rhenen A."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/pages | "2659-2666"xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/title | "The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells."xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/17609428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17609428 |
| http://purl.uniprot.org/citations/17609428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17609428 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T2-mappedCitation-17609428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609428 |
| http://purl.uniprot.org/uniprot/#_Q504P2-mappedCitation-17609428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17609428 |
| http://purl.uniprot.org/uniprot/Q504P2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17609428 |
| http://purl.uniprot.org/uniprot/A0A0R4J0T2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17609428 |