| http://purl.uniprot.org/citations/17610414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17610414 | http://www.w3.org/2000/01/rdf-schema#comment | "Human B7-H3, a novel member of B7 family, has two isoforms (2IgB7-H3 and 4IgB7-H3). As costimulatory functions of both isoforms are not clarified, there has been much discussion on their expression patterns, T-cell responses, etc. This study generated two specific mouse anti-human 2IgB7-H3 monoclonal antibodies (mAbs) (7D7 and 10F1), whose specificities are quite different from those of the available B7-H3 mAb (21D4) by competition assay. The use of antibodies indicated that B7-H3 was found to have different expression patterns on monocyte-derived dendritic cells, that is the isoform 2IgB7-H3 is tended to express on immature dendritic cells (iDCs), whereas 4IgB7-H3 could be detected in the whole process of maturation of dendritic cells. The isoform 4IgB7-H3 was shown in the immunohistochemistry assay to be more widely expressed than 2IgB7-H3 in human benign and malignant hepatic tissues. Furthermore, flow cytometry and reverse transcription-polymerase chain reaction indicated that 4IgB7-H3 rather than 2IgB7-H3 was the major isoform on many human tumor cell lines. In addition, both 2IgB7-H3- and 4IgB7-H3-transfected cells could promote T-cell proliferation, which could be blocked by 7D7 mAb. These two novel antibodies may shed light on the function of the two B7-H3 isoforms."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2007.00853.x"xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Ge Y."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Chen Y.J."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Zhou Y.H."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Xie F."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Zhang X.G."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Wang X.F."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Zhang G.B."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/author | "Ma Z.Y."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/pages | "96-104"xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/title | "4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells."xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/17610414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17610414 |
| http://purl.uniprot.org/citations/17610414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17610414 |
| http://purl.uniprot.org/uniprot/#_A6MDC5-mappedCitation-17610414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17610414 |
| http://purl.uniprot.org/uniprot/#_Q8VE98-mappedCitation-17610414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17610414 |
| http://purl.uniprot.org/uniprot/A6MDC5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17610414 |
| http://purl.uniprot.org/uniprot/Q8VE98 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17610414 |