| http://purl.uniprot.org/citations/17610843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17610843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17610843 | http://www.w3.org/2000/01/rdf-schema#comment | "The hypoxic response of mammalian cells is controlled through a transcriptional pathway that is mediated by the hypoxia-inducible factor (HIF). Here, we show that HIF-1alpha undergoes post-translational modification by the three isoforms of the small ubiquitin-related modifier (SUMO-1, -2 and -3) in vitro in proximity to and within the oxygen-dependent degradation domain (ODDD). SUMO conjugation is promoted in vitro by the E3 SUMO ligase RanBP2/Nup538 and SUMO modification in vivo does not change HIF-1alpha turnover rate. Using cotransfection of siRNA targeted to endogenous HIF-1alpha together with HIF-1alpha siRNA-resistant expression vectors carrying mutations for SUMO modification we demonstrate increased hypoxia-response element-dependent transcriptional activity for SUMO-deficient HIF-1alpha. These results indicate that when HIF-1alpha is conjugated to SUMO its transcriptional activity is decreased and that this is not mediated by a change in the protein's half-life."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.06.103"xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.06.103"xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Pouyssegur J."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Pouyssegur J."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Mazure N."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Mazure N."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Berta M.A."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Berta M.A."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Brahimi-Horn M.C."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Brahimi-Horn M.C."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Hattab M."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/author | "Hattab M."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/pages | "646-652"xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/pages | "646-652"xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/title | "SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/title | "SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/17610843 | http://purl.uniprot.org/core/volume | "360"xsd:string |