| http://purl.uniprot.org/citations/17610895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17610895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17610895 | http://www.w3.org/2000/01/rdf-schema#comment | "The dystrophin-related and -associated protein dystrobrevin is a component of the dystrophin-associated protein complex, which directly links the cytoskeleton to the extracellular matrix. It is now thought that this complex also serves as a dynamic scaffold for signaling proteins, and dystrobrevin may play a role in this context. Since dystrobrevin involvement in signaling pathways seems to be dependent on its interaction with other proteins, we sought new insights and performed a two-hybrid screen of a mouse brain cDNA library using beta-dystrobrevin, the isoform expressed in non-muscle tissues, as bait. Among the positive clones characterized after the screen, one encodes the regulatory subunit RIalpha of the cAMP-dependent protein kinase A (PKA). We confirmed the interaction by in vitro and in vivo association assays, and mapped the binding site of beta-dystrobrevin on RIalpha to the amino-terminal region encompassing the dimerization/docking domain of PKA regulatory subunit. We also found that the domain of interaction for RIalpha is contained in the amino-terminal region of beta-dystrobrevin. We obtained evidence that beta-dystrobrevin also interacts directly with RIIbeta, and that not only beta-dystrobrevin but also alpha-dystrobrevin interacts with PKA regulatory subunits. We show that both alpha and beta-dystrobrevin are specific phosphorylation substrates for PKA and that protein phosphatase 2A (PP2A) is associated with dystrobrevins. Our results suggest a new role for dystrobrevin as a scaffold protein that may play a role in different cellular processes involving PKA signaling."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2007.06.019"xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2007.06.019"xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Macchia G."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Macchia G."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Grasso M."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Grasso M."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Petrucci T.C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Petrucci T.C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Macioce P."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Macioce P."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Ceccarini M."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Ceccarini M."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Artegiani B."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Artegiani B."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Gambara G."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Gambara G."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Mallozzi C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Mallozzi C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Ramoni C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Ramoni C."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Torreri P."xsd:string |
| http://purl.uniprot.org/citations/17610895 | http://purl.uniprot.org/core/author | "Torreri P."xsd:string |