| http://purl.uniprot.org/citations/17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17612494 | http://www.w3.org/2000/01/rdf-schema#comment | "E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle selective, and HCF-1 displays coactivator properties when bound to the E2F1 activator and corepressor properties when bound to the E2F4 repressor. During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. These results suggest that HCF-1 induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.05.030"xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/author | "Tyagi S."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/author | "Herr W."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/author | "Wysocka J."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/author | "Chabes A.L."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/pages | "107-119"xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/title | "E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases."xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17612494 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17612494 |
| http://purl.uniprot.org/citations/17612494 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17612494 |
| http://purl.uniprot.org/uniprot/#_A0A223PQH6-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q15291-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q05C05-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_O15047-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_P51610-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_P61964-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q6UXN9-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q9C005-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q9UBL3-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/#_Q9P0U4-mappedCitation-17612494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612494 |
| http://purl.uniprot.org/uniprot/A0A223PQH6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17612494 |