| http://purl.uniprot.org/citations/17612500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17612500 | http://www.w3.org/2000/01/rdf-schema#comment | "Role of c-Src in muscle differentiation has been controversial. Here, we investigated if c-Src positively or negatively regulates muscle differentiation, using H9c2 and C2C12 cell lines. Inhibition of c-Src by treatment with PP1 and SU6656, pharmacologic inhibitors of Src family kinases, or by expression of a dominant negative c-Src, all induced muscle differentiation in proliferation medium (PM). In differentiating cells in differentiation medium (DM), c-Src activity gradually decreased and reached basal level 3 days after induction of differentiation. Inhibition of c-Src suppressed Raf/MEK/ERK pathway but activated p38 MAPK. Inhibition of p38 MAPK did not affect c-Src activity in PM. However, it reactivated Raf/MEK/ERK pathway in c-Src-inhibited cells regardless of PM or DM. Concomitant inhibition of c-Src and p38 MAPK activities blocked muscle differentiation in both media. In conclusion, suppression of c-Src activity stimulates muscle differentiation by activating p38 MAPK uni-directionally."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2007.06.004"xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Kim S.S."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Kang I."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Seo Y.H."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Ha J."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Cho C.H."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Jung C.Y."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Kim B.S."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Lim M.J."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/author | "Choi K.J."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/pages | "197-208"xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/title | "Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation."xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://purl.uniprot.org/core/volume | "465"xsd:string |
| http://purl.uniprot.org/citations/17612500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17612500 |
| http://purl.uniprot.org/citations/17612500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17612500 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STA1-mappedCitation-17612500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612500 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQQ5-mappedCitation-17612500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612500 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SR46-mappedCitation-17612500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17612500 |