| http://purl.uniprot.org/citations/17613434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17613434 | http://www.w3.org/2000/01/rdf-schema#comment | "Although PML-enforced RARA homodimerization allows PML/RARA to bind DNA independently of its coreceptor RXR, the latter was identified within the PML/RARA complex. We demonstrate that a PML/RARA mutant defective for RXR binding fails to trigger APL development in transgenic mice, although it still transforms primary hematopoietic progenitors ex vivo. RXR enhances PML/RARA binding to DNA and is required for rexinoid-induced APL differentiation. In RA-treated PML/RARA-transformed cells, the absence of RXR binding results in monocytic, rather than granulocytic, differentiation. PML/RARA enhances posttranslational modifications of RXRA, including its sumoylation, suggesting that PML-bound sumoylation enzymes target RXRA and possibly other PML/RARA-bound chromatin proteins, further contributing to deregulated transcription. Thus, unexpectedly, RXR contributes to several critical aspects of in vivo transformation."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2007.06.004"xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Honore N."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "de The H."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Nasr R."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Vitoux D."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Lavau C."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Berthier C."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Kamashev D."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Peres L."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/author | "Riaucoux-Lormiere F."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/pages | "23-35"xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/title | "RXR is an essential component of the oncogenic PML/RARA complex in vivo."xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/17613434 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17613434 |
| http://purl.uniprot.org/citations/17613434 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17613434 |
| http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-17613434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17613434 |
| http://purl.uniprot.org/uniprot/#_D3YXR5-mappedCitation-17613434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17613434 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MP91-mappedCitation-17613434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17613434 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MQ23-mappedCitation-17613434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17613434 |