| http://purl.uniprot.org/citations/17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17615582 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock protein 110 (hsp110) and glucose-regulated protein (grp170) act as anti-cancer vaccines when complexed to tumor antigens by heat shock. It has been proposed that receptors on antigen-presenting cells contribute to HSP-mediated immune responses. Here, we show that hsp110 binds in a receptor-mediated manner to RAW264.7 macrophages, as does grp170. This hsp110/grp170 binding is inhibited by scavenger receptor ligands, suggesting a role for scavenger receptors as binding structures. We examined scavenger receptor class A (SR-A) and scavenger receptor expressed by endothelial cells-I (SREC-I). We show that hsp110/grp170 binds to both SR-A- and SREC-I-expressing CHO cells in a saturable manner and scavenger receptor ligands inhibit binding. Hsp110 also saturably binds mouse bone marrow-derived dendritic cells (bmDC) and is inhibited by scavenger receptor ligands. When an hsp110-rat neu (intracellular domain) heat shock complex vaccine is used to pulse mouse bmDC in vitro, an induction of IFN-gamma secretion is observed by CD8+ T lymphocytes isolated from vaccine-immunized mice. This immune response is inhibited by the application of scavenger receptor ligands to bmDC. Thus, SR-A and SREC-I appear to contribute to the binding of hsp110 and grp170 on APC. Scavenger receptors, in general, contribute to the cross-presentation of hsp110-chaperoned protein antigen."xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737127"xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/author | "Wang X.Y."xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/author | "Subjeck J.R."xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/author | "Facciponte J.G."xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/pages | "2268-2279"xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/title | "Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I."xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/17615582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17615582 |
| http://purl.uniprot.org/citations/17615582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17615582 |
| http://purl.uniprot.org/uniprot/#_Q14162-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_Q3U2C3-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_Q92598-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_Q8CED7-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_P07900-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_P04114-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_P30204-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_P27797-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_Q3U3E5-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/#_Q9Y4L1-mappedCitation-17615582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17615582 |
| http://purl.uniprot.org/uniprot/Q9Y4L1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17615582 |