| http://purl.uniprot.org/citations/17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17616707 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunization of mice with human dopachrome tautomerase (hDCT) provides greater protection against melanoma than immunization with the murine homologue (mDCT). We mapped the CD8(+) and CD4(+) T-cell epitopes in both proteins to better understand the mechanisms of the enhanced protection. The dominant CD8(+) T-cell epitopes were fully conserved between both proteins, yet immunization with hDCT produced frequencies of CD8(+) T cells that were 5-to 10-fold higher than immunization with mDCT. This difference was not intrinsic to the two proteins because comparable frequencies of CD8(+) T cells were elicited by both antigens in DCT-deficient mice. Strikingly, only hDCT elicited a significant level of specific CD4(+) T cells in wild-type (WT) mice. The murine protein was not devoid of CD4(+) T-cell epitopes because immunization of DCT-deficient mice with mDCT resulted in robust CD4(+) T-cell immunity directed against two epitopes that were not identified in WT mice. These results suggested that the reduced immunogenicity of mDCT in WT mice may be a function of insufficient CD4(+) T-cell help. To address this possibility, the dominant CD4(+) T-cell epitope from hDCT was introduced into mDCT. Immunization with the mutated mDCT evoked CD8(+) T-cell frequencies and protective immunity comparable with hDCT. These results reveal a novel mechanism by which xenoantigens overcome tolerance. Our data also suggest that immunologic tolerance is more stringent for CD4(+) T cells than CD8(+) T cells, providing a mechanism of peripheral tolerance where autoreactive CD8(+) T cells fail to be activated due to a lack of autoreactive CD4(+) T cells specific for the same antigen."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-4336"xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Wan Y."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Cheng S."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Bernard D."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Beermann F."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Marshall L.A."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Bramson J."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Grinshtein N."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Kianizad K."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/author | "Margl R."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/pages | "6459-6467"xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/title | "Elevated frequencies of self-reactive CD8+ T cells following immunization with a xenoantigen are due to the presence of a heteroclitic CD4+ T-cell helper epitope."xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17616707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17616707 |
| http://purl.uniprot.org/citations/17616707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17616707 |
| http://purl.uniprot.org/uniprot/#_B2CY76-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |
| http://purl.uniprot.org/uniprot/#_Q8BSF9-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |
| http://purl.uniprot.org/uniprot/#_Q8CAX3-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |
| http://purl.uniprot.org/uniprot/#_P29812-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |
| http://purl.uniprot.org/uniprot/#_Q3UUV7-mappedCitation-17616707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17616707 |