| http://purl.uniprot.org/citations/17616937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17616937 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock proteins (HSPs) play an important role in the cellular response to environmental stress and exert a cytoprotective effect. Especially HSP70 is an effective inhibitor of apoptosis, suggesting a role of HSP70 in carcinogenesis and tumor progression. To explore the relevance of HSP70 in renal cell carcinomas (RCCs), we analyzed nuclear and cytoplasmic HSP70 protein expression in formalin-fixed tissue from 145 clear cell RCCs by immunohistochemistry as well as Western blot analysis. Nuclear HSP70 expression was found in all RCCs and 75% of the tumors also exhibited a cytoplasmic HSP70 staining. Importantly, RCCs showed significantly reduced cytoplasmic (p=0.001) and combined nuclear/cytoplasmic (p=0.0022) HSP70 expression when compared with their cells of origin. A significant (p=0.0176) decrease of nuclear HSP70 expression became evident from well to poorly differentiated clear cell RCCs. Quite similarly, a trend (p=0.0558) for reduced combined nuclear/cytoplasmic HSP70 expression was shown from early (pT1) to advanced (pT3) tumor stages. Nevertheless, no correlation between HSP70 expression and patients survival became evident. In conclusion, our investigation demonstrates a significant decrease of antiapoptotic HSP70 protein expression during carcinogenesis and during progression from well (G1) to poorly (G3) differentiated clear cell RCCs. Our results suggest that HSP70-mediated inhibition of apoptosis seems to be of minor importance for carcinogenesis and tumor progression in RCCs."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.org/dc/terms/identifier | "doi:10.14670/hh-22.1099"xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Shibata T."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Gabbert H.E."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Mahotka C."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Heikaus S."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Ramp U."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Willers R."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/author | "Grimm M.O."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/name | "Histol Histopathol"xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/pages | "1099-1107"xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/title | "Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis."xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/17616937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17616937 |
| http://purl.uniprot.org/citations/17616937 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17616937 |
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