| http://purl.uniprot.org/citations/17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17617740 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expression. Exposure to IFNalpha resulted in concentration-dependent induction of TRAIL and apoptosis. Inhibition of TRAIL or downstream components of the TRAIL cell death pathway (FADD, caspase-8) via siRNA-mediated knockdown attenuated IFNalpha-induced cell death, thereby implicating TRAIL in the response. IFNalpha induced rapid STAT-1 phosphorylation and DNA binding activity and subsequent accumulation of IRF-1. Transfection with siRNAs directed against STAT-1 or IRF-1 inhibited IFNalpha-induced TRAIL production and cell death, and chromatin immunprecipitation (ChIP) analyses demonstrated that IFNalpha induced direct, time-dependent binding of both transcription factors to the TRAIL promoter. Together, our results demonstrate that IFNalpha induces TRAIL expression via a STAT-1/IRF-1-dependent mechanism in human bladder cancer cells, and this induction of TRAIL plays an important role in IFNalpha-induced cell killing."xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.org/dc/terms/identifier | "doi:10.4161/cbt.6.6.4088"xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/author | "Papageorgiou A."xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/author | "Dinney C.P."xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/author | "McConkey D.J."xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/name | "Cancer Biol Ther"xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/pages | "872-879"xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/title | "Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/17617740 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17617740 |
| http://purl.uniprot.org/citations/17617740 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A0U5EM55-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK53-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK11-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A1B1RS94-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_A5D905-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_D2KFR9-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_P50591-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |
| http://purl.uniprot.org/uniprot/#_P10914-mappedCitation-17617740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17617740 |