| http://purl.uniprot.org/citations/17618271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17618271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17618271 | http://www.w3.org/2000/01/rdf-schema#comment | "Central to innate immunity is the sensing of pathogen-associated molecular patterns by cytosolic and membrane-associated receptors. In particular, DNA is a potent activator of immune responses during infection or tissue damage, and evidence indicates that, in addition to the membrane-associated Toll-like receptor 9, an unidentified cytosolic DNA sensor(s) can activate type I interferon (IFN) and other immune responses. Here we report on a candidate DNA sensor, previously named DLM-1 (also called Z-DNA binding protein 1 (ZBP1)), for which biological function had remained unknown; we now propose the alternative name DAI (DNA-dependent activator of IFN-regulatory factors). The artificial expression of otherwise IFN-inducible DAI (DLM-1/ZBP1) in mouse fibroblasts selectively enhances the DNA-mediated induction of type I IFN and other genes involved in innate immunity. On the other hand, RNA interference of messenger RNA for DAI (DLM-1/ZBP1) in cells inhibits this gene induction programme upon stimulation by DNA from various sources. Moreover, DAI (DLM-1/ZBP1) binds to double-stranded DNA and, by doing so, enhances its association with the IRF3 transcription factor and the TBK1 serine/threonine kinase. These observations underscore an integral role of DAI (DLM-1/ZBP1) in the DNA-mediated activation of innate immune responses, and may offer new insight into the signalling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06013"xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06013"xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Yanai H."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Yanai H."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Miyagishi M."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Miyagishi M."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Ban T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Ban T."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Takaoka A."xsd:string |
| http://purl.uniprot.org/citations/17618271 | http://purl.uniprot.org/core/author | "Takaoka A."xsd:string |