| http://purl.uniprot.org/citations/17620332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17620332 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Abl is a cytoplasmic tyrosine kinase involved in several signal transduction pathways. Here we report that c-Abl is involved also in insulin receptor signaling. Indeed, c-Abl tyrosine kinase is activated upon insulin stimulation. Inhibition of c-Abl tyrosine kinase by STI571 attenuates the effect of insulin on Akt/GSK-3beta phosphorylation and glycogen synthesis, and at the same time, it enhances the effect of insulin on ERK activation, cell proliferation, and migration. This effect of STI571 is specific to c-Abl inhibition, because it does not occur in Abl-null cells and is restored in c-Abl-reconstituted cells. Numerous evidences suggest that focal adhesion kinase (FAK) is involved in mediating this c-Abl effect. First, anti-phosphotyrosine blots indicate that c-Abl tyrosine kinase activation is concomitant with FAK dephosphorylation in response to insulin, whereas c-Abl inhibition is accompanied by FAK phosphorylation in response to insulin, a response similar to that observed with IGF-I. Second, the c-Abl effects on insulin signaling are not observed in cells devoid of FAK (FAK(-/-) cells). Taken together these results suggest that c-Abl activation by insulin, via a modification of FAK response, may play an important role in directing mitogenic versus metabolic insulin receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705008200"xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Belfiore A."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Vigneri R."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Frasca F."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Pandini G."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Sciacca L."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Mandarino A."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Malaguarnera R."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/author | "Messina R.L."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/pages | "26077-26088"xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/title | "Role of c-Abl in directing metabolic versus mitogenic effects in insulin receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17620332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17620332 |
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