| http://purl.uniprot.org/citations/17621610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17621610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17621610 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we examine the potential role of receptor-associated protein 80 (RAP80), a nuclear protein containing two ubiquitin-interacting motifs (UIM), in DNA damage response and double-strand break (DSB) repair. We show that following ionizing radiation and treatment with DNA-damaging agents, RAP80 translocates to discrete nuclear foci that colocalize with those of gamma-H2AX. The UIMs and the region of amino acids 204 to 304 are critical for the relocalization of RAP80 to ionizing radiation-induced foci (IRIF). These observations suggest that RAP80 becomes part of a DNA repair complex at the sites of IRIF. We also show that RAP80 forms a complex with the tumor repressor BRCA1 and that this interaction is mediated through the BRCA1 COOH-terminal repeats of BRCA1. The UIMs are not required for the interaction of RAP80 with BRCA1. Knockdown of RAP80 in HEK293 cells significantly reduced DSB-induced homology-directed recombination (HDR). Moreover, inhibition of RAP80 expression by small interfering RNA increased radiosensitivity, whereas increased radioresistance was observed in human breast cancer MCF-7 cells with overexpression of RAP80. Taken together, our data suggest that RAP80 plays an important role in DNA damage response signaling and HDR-mediated DSB repair. We further show that RAP80 can function as a substrate of the ataxia-telangiectasia mutated protein kinase in vitro, which phosphorylates RAP80 at Ser(205) and Ser(402). We show that this phosphorylation is not required for the migration of RAP80 to IRIF."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-0924"xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-0924"xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Liao G."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Liao G."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Yang X.-P."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Yang X.-P."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Xia F."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Xia F."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Li L.-P."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/author | "Li L.-P."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/pages | "6647-6656"xsd:string |
| http://purl.uniprot.org/citations/17621610 | http://purl.uniprot.org/core/pages | "6647-6656"xsd:string |