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| http://purl.uniprot.org/citations/17622316 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV-1 Vpr plays a pivotal role in viral pathogenesis and is preferentially targeted by the host immune system. In this report, we demonstrate that a small heat shock protein, HSP27, exhibits Vpr-specific antiviral activity, as its expression is specifically responsive to vpr gene expression and increased levels of HSP27 inhibit Vpr-induced cell cycle G2 arrest and cell killing. We further show that overexpression of HSP27 reduces viral replication in T-lymphocytes in a Vpr-dependent manner. Mechanistically, Vpr triggers HSP27 expression through heat shock factor (HSF) 1, but inhibits prolonged expression of HSP27 under heat-shock conditions. Together, these data suggest a potential dynamic and antagonistic interaction between HIV-1 Vpr and a host cell HSP27, suggesting that HSP27 may contribute to cellular intrinsic immunity against HIV infection."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.org/dc/terms/identifier | "doi:10.2119/2007-00004.liang"xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/author | "Liang D."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/author | "Benko Z."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/author | "Bukrinsky M."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/author | "Zhao R.Y."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/author | "Agbottah E."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/name | "Mol Med"xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/pages | "229-239"xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/title | "Anti-vpr activities of heat shock protein 27."xsd:string |
| http://purl.uniprot.org/citations/17622316 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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