| http://purl.uniprot.org/citations/17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17626781 | http://www.w3.org/2000/01/rdf-schema#comment | "Low levels of hydrogen peroxide (H(2)O(2)) are mitogenic to mammalian cells and stimulate the hyperphosphorylation of heterogeneous nuclear ribonucleoprotein C (hnRNP-C) by protein kinase CK1alpha. However, the mechanisms by which CK1alpha is regulated have been unclear. Here it is demonstrated that low levels of H(2)O(2) stimulate the rapid dephosphorylation of CK1alphaLS, a nuclear splice form of CK1alpha. Furthermore, it is demonstrated that either treatment of endothelial cells with H(2)O(2), or dephosphorylation of CK1alphaLS in vitro enhances the association of CK1alphaLS with hnRNP-C. In addition, dephosphorylation of CK1alphaLS in vitro enhances the kinase's ability to phosphorylate hnRNP-C. While CK1alpha appears to be present in all metazoans, analysis of CK1alpha genomic sequences from several species reveals that the alternatively spliced nuclear localizing L-insert is unique to vertebrates, as is the case for hnRNP-C. These observations indicate that CK1alphaLS and hnRNP-C represent conserved components of a vertebrate-specific H(2)O(2)-responsive nuclear signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2007.06.010"xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/author | "Stone J.R."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/author | "Bedri S."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/author | "Cizek S.M."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/author | "Rastarhuyeva I."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/pages | "242-249"xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/title | "Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxide."xsd:string |
| http://purl.uniprot.org/citations/17626781 | http://purl.uniprot.org/core/volume | "466"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B4DFH4-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
| http://purl.uniprot.org/uniprot/#_B4E1D9-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
| http://purl.uniprot.org/uniprot/#_B4DER9-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
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| http://purl.uniprot.org/uniprot/#_Q8WXF2-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
| http://purl.uniprot.org/uniprot/#_Q6PJ06-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
| http://purl.uniprot.org/uniprot/#_Q9P137-mappedCitation-17626781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17626781 |
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