| http://purl.uniprot.org/citations/17629760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17629760 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in human caveolin-3 are known to underlie a range of myopathies. The cav-1 gene of Caenorhabditis elegans is a homologue of human caveolin-3 and is expressed in both neurons and body wall muscles. Within the body wall muscle CAV-1 localises adjacent to neurons, most likely at the neuromuscular junction (NMJ). Using fluorescently tagged CAV-1 and pre- and post-synaptic markers we demonstrate that CAV-1 co-localises with UNC-63, a post-synaptic marker, but not with several pre-synaptic markers. To establish a model for human muscular dystrophies caused by dominant-negative mutations in caveolin-3 we created transgenic animals carrying versions of cav-1 with homologous mutations. These animals had increased sensitivity to levamisole, suggesting a role for cav-1 at the NMJ. Animals carrying a deletion in cav-1 show a similar sensitivity. Sensitivity to levamisole and locomotion were also perturbed in animals carrying a dominant-negative cav-1 and a mutation in dynamin, which is a protein known to interact with caveolins. Thus, indicating an interaction between CAV-1 and dynamin at the NMJ and/or in neurons."xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10158-007-0051-5"xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/author | "Baylis H.A."xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/author | "Parker S."xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/author | "Peterkin H.S."xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/name | "Invert Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/pages | "157-164"xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/title | "Muscular dystrophy associated mutations in caveolin-1 induce neurotransmission and locomotion defects in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17629760 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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