| http://purl.uniprot.org/citations/17630342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17630342 | http://www.w3.org/2000/01/rdf-schema#comment | "Since the neurohypophyseal hormone 8-arginine vasopressin (AVP) is involved in cardiovascular tissue hypertrophy and myocyte differentiation, it is possible that local AVP plays a role in heart maturation. AVP-specific RIA, RT-PCR, and immunoblot measurement of AVP receptors (VR) were used to investigate heart tissues from newborn and adult rats. To test AVP's role in differentiation and specialization into ventricle-like cardiomyocytes, we studied GFP-P19Cl6 stem cells, which express green fluorescence protein (GFP) reporter under transcriptional control of the myosin light chain-2v promoter. VR(1) transcripts and proteins were higher in adult than in newborn rat hearts. In contrast, VR(2) increased from postnatal day 1 to 5 and was barely detected in the adult rat heart. In cardiomyocytes expressing troponin C, immunofluorescence revealed VR(2) and VR(1). Intracellular cAMP increased 6.5- and 8.9-fold in response to the selective VR(2) agonist 1-desamino-8-D-AVP (DDAVP) after 1 and 24 h, respectively. Cardiac AVP was high in 1- and 5-day-old (330 +/- 26 and 276 +/-53 pg/mg protein, respectively) but low in 66-day-old (98 +/-15 pg/mg protein) rats. AVP immunostaining was detected in the tunica adventitia and endothelium of the coronary vessels. The possible role of AVP in cardiomyogenesis was indicated by DDAVP-AVP-dependent differentiation of GFP-P19Cl6 stem cells into contracting cells displaying GATA-4, a cardiac-specific marker, and ventricle-specific myosin light chain. Together, it is suggested that the AVP system is implicated in postnatal cardiac maturation."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.01320.2006"xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Gutkowska J."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Jankowski M."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Danalache B."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Gassanov N."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/author | "Miszkurka M."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/pages | "H2262-70"xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/title | "Functional arginine vasopressin system in early heart maturation."xsd:string |
| http://purl.uniprot.org/citations/17630342 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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