| http://purl.uniprot.org/citations/17630352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17630352 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This suggests that antigenic presentation of EBV-derived peptides in the context of HLA-A is involved in the pathogenesis of EBV+ HL by precluding efficient immune responses. We genotyped exons 2 and 3, encoding the peptide-binding groove of HLA-A, for 32 single nucleotide polymorphisms in 70 patients with EBV+ HL, 31 patients with EBV-HL, and 59 control participants. HLA-A*01 was significantly overrepresented and HLA-A*02 was significantly underrepresented in patients with EBV+ HL versus controls and patients with EBV-HL. In addition, HLA-A*02 status was determined by immunohistochemistry or HLA-A*02-specific polymerase chain reaction (PCR) on 152 patients with EBV+ HL and 322 patients with EBV-HL. The percentage of HLA-A*02+ patients in the EBV+ HL group (35.5%) was significantly lower than in 6107 general control participants (53.0%) and the EBV-HL group (50.9%). Our results indicate that individuals carrying the HLA-A*02 allele have a reduced risk of developing EBV+ HL, while individuals carrying the HLA-A*01 allele have an increased risk. It is known that HLA-A*02 can present EBV-derived peptides and can evoke an effective immune response, which may explain the protective phenotype."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-05-086934"xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Nolte I.M."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Visser L."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Gallagher A."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Diepstra A."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "van den Berg A."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Poppema S."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "te Meerman G.J."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Jarrett R.F."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Kouprie N."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Hepkema B."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Platteel M."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Delury C.P."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/author | "Niens M."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/pages | "3310-3315"xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/title | "HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma."xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/17630352 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17630352 |
| http://purl.uniprot.org/citations/17630352 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17630352 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-17630352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17630352 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-17630352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17630352 |