| http://purl.uniprot.org/citations/17636019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17636019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17636019 | http://www.w3.org/2000/01/rdf-schema#comment | "Gfi1 transcriptionally governs hematopoiesis, and its mutations produce neutropenia. In an effort to identify Gfi1-interacting proteins and also to generate new candidate genes causing neutropenia, we performed a yeast two-hybrid screen with Gfi1. Among other Gfi1-interacting proteins, we identified a previously uncharacterized member of the PR domain-containing family of tumor suppressors, PRDM5. PRDM5 has 16 zinc fingers, and we show that it acts as a sequence-specific, DNA binding transcription factor that targets hematopoiesis-associated protein-coding and microRNA genes, including many that are also targets of Gfi1. PRDM5 epigenetically regulates transcription similarly to Gfi1: it recruits the histone methyltransferase G9a and class I histone deacetylases to its target gene promoters and demonstrates repressor activity on synthetic reporters; on endogenous target genes, however, it functions as an activator, in addition to a repressor. Interestingly, genes that PRDM5 activates, as opposed to those it represses, are also targets of Gfi1, suggesting a competitive mechanism through which two repressors could cooperate in order to become transcriptional activators. In neutropenic patients, we identified PRDM5 protein sequence variants perturbing transcriptional function, suggesting a potentially important role in hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00762-07"xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00762-07"xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Horwitz M.S."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Horwitz M.S."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Duan Z."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Duan Z."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Grimes H.L."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Grimes H.L."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Papayannopoulou T."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Papayannopoulou T."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Person R.E."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Person R.E."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Badolato R."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Badolato R."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Lee H.-H."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Lee H.-H."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Donadieu J."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/author | "Donadieu J."xsd:string |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17636019 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |