| http://purl.uniprot.org/citations/17636028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17636028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17636028 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies of a TAZ knockout mouse reveal a novel function of the transcriptional regulator TAZ, that is, as a binding partner of the F-box protein beta-Trcp. TAZ-/-mice develop polycystic kidney disease (PKD) and emphysema. The calcium-permeable cation channel protein polycystin 2 (PC2) is overexpressed in kidneys of TAZ-/-mice as a result of decreased degradation via an SCF(beta-Trcp) E3 ubiquitin ligase pathway. Replacements of serines in a phosphodegron motif in TAZ prevent beta-Trcp binding and PC2 degradation. Coexpression of a cytoplasmic fragment of polycystin 1 blocks the PC2-TAZ interaction and prevents TAZ-mediated degradation of PC2. Depletion of TAZ in zebrafish also results in a cystic kidney accompanied by overexpression of PC2. These results establish a common role of TAZ across vertebrate species in a protein degradation pathway regulated by phosphorylation and implicate deficiencies in this pathway in the development of PKD."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00254-07"xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "You J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "You J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Hong J.H."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Hong J.H."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Carroll J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Carroll J."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Bronson R."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Bronson R."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Benjamin T."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Benjamin T."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Kolb R."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/author | "Kolb R."xsd:string |
| http://purl.uniprot.org/citations/17636028 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |