| http://purl.uniprot.org/citations/17636479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17636479 | http://www.w3.org/2000/01/rdf-schema#comment | "Although Ca(2+)-dependent signaling pathways are important for skeletal muscle plasticity, the sources of Ca(2+) that activate these signaling pathways are not completely understood. Influx of Ca(2+) through surface membrane Ca(2+) channels may activate these pathways. We examined expression of two L-type Ca(2+) channels in adult skeletal muscle, the Ca(V) 1.1 and Ca(V) 1.2, with isoform-specific antibodies in Western blots and immunocytochemistry assays. Consistent with a large body of work, expression of the Ca(V) 1.1 was restricted to skeletal muscle where it was expressed in T-tubules. Ca(V) 1.2 was also expressed in skeletal muscle, in the sarcolemma of type I and IIa myofibers. Exercise-induced alterations in muscle fiber types cause a concomitant increase in the number of both Ca(V) 1.2 and type IIa-positive fibers. Taken together, these data suggest that the Ca(V) 1.2 Ca(2+) channel is expressed in adult skeletal muscle in a fiber type-specific manner, which may help to maintain oxidative muscle phenotype."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.org/dc/terms/identifier | "doi:10.1002/mus.20842"xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Rich M.M."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Kraner S.D."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Wang Q.B."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Hebert S.L."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Jeftinija D.M."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/author | "Norris C.M."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/name | "Muscle Nerve"xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/pages | "482-490"xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/title | "The Ca(V) 1.2 Ca(2+) channel is expressed in sarcolemma of type I and IIa myofibers of adult skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/17636479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17636479 |
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