| http://purl.uniprot.org/citations/17638845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17638845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17638845 | http://www.w3.org/2000/01/rdf-schema#comment | "The mucin-like protein CD43 is excluded from the immune synapse, and regulates T-cell proliferation as well as T-cell migration. While the CD43 cytoplasmic domain is necessary for regulation of T-cell activation and proliferation, the mechanism via which CD43 regulates trafficking is not well defined. To investigate whether CD43 phosphorylation regulates its function in T cells, we used tandem mass spectrometry and identified Ser76 in murine CD43 as a previously unidentified site of basal phosphorylation. Interestingly, mutation of this single serine to alanine greatly diminishes T-cell trafficking to the lymph node, while CD43 exclusion and CD43-mediated regulation of T-cell proliferation remain intact. Furthermore, the CD43 extracellular domain was also required for T-cell trafficking, providing a hitherto unknown function for the extracellular domain, and suggesting that the extracellular domain may be required to transduce signals via the cytoplasmic domain. These data reveal a novel mechanism by which CD43 regulates T-cell function, and suggest that CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-01-065276"xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-01-065276"xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Blaine K.M."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Blaine K.M."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Cannon J.L."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Cannon J.L."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Mody P.D."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Mody P.D."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Sperling A.I."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Sperling A.I."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Bandukwala H.S."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Bandukwala H.S."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Schilling A.B."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Schilling A.B."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Swier K."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/author | "Swier K."xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/pages | "2974-2982"xsd:string |
| http://purl.uniprot.org/citations/17638845 | http://purl.uniprot.org/core/pages | "2974-2982"xsd:string |