| http://purl.uniprot.org/citations/17639080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17639080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17639080 | http://www.w3.org/2000/01/rdf-schema#comment | "The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We present evidence to implicate Hop2 as the major DNA-binding subunit and Mnd1 as the prominent Rad51 interaction entity. Hop2-Mnd1 stabilizes the Rad51-single-stranded DNA (ssDNA) nucleoprotein filament, the catalytic intermediate in recombination reactions. We also show that Hop2-Mnd1 enhances the ability of the Rad51-ssDNA nucleoprotein filament to capture duplex DNA, an obligatory step in the formation of the synaptic complex critical for DNA joint formation. Thus, our results unveil a bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1563007"xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1563007"xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Chi P."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Chi P."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Petukhova G.V."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Petukhova G.V."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "San Filippo J."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "San Filippo J."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Sehorn M.G."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/author | "Sehorn M.G."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/pages | "1747-1757"xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/pages | "1747-1757"xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/title | "Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/title | "Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase."xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17639080 | http://purl.uniprot.org/core/volume | "21"xsd:string |