| http://purl.uniprot.org/citations/17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17639083 | http://www.w3.org/2000/01/rdf-schema#comment | "Termination of RNA polymerase II transcription frequently requires a poly(A) signal and cleavage/polyadenylation factors. Recent work has shown that degradation of the downstream cleaved RNA by the exonuclease XRN2 promotes termination, but how XRN2 functions with 3'-processing factors to elicit termination remains unclear. Here we show that XRN2 physically associates with 3'-processing factors and accumulates at the 3' end of a transcribed gene. In vitro 3'-processing assays show that XRN2 is necessary to degrade the downstream RNA, but is not required for 3' cleavage. Significantly, degradation of the 3'-cleaved RNA was stimulated when coupled to cleavage. Unexpectedly, while investigating how XRN2 is recruited to the 3'-processing machinery, we found that XRN2 associates with p54nrb/NonO(p54)-protein-associated splicing factor (PSF), multifunctional proteins involved in several nuclear processes. Strikingly, p54 is also required for degradation of the 3'-cleaved RNA in vitro. p54 is present along the length of genes, and small interfering RNA (siRNA)-mediated knockdown leads to defects in XRN2 recruitment and termination. Together, our data indicate that p54nrb/PSF functions in recruitment of XRN2 to facilitate pre-mRNA 3' processing and transcription termination."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1565207"xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/author | "Rozenblatt-Rosen O."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/author | "Kaneko S."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/author | "Manley J.L."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/author | "Meyerson M."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/pages | "1779-1789"xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/title | "The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination."xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17639083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17639083 |
| http://purl.uniprot.org/citations/17639083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17639083 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Z9-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_Q15559-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4E7-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_A0A384N5Z8-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_A2RRQ1-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_B3KMC9-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_B4E0B9-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_B4DZC3-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_A8K525-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_P23246-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |
| http://purl.uniprot.org/uniprot/#_Q15233-mappedCitation-17639083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639083 |